Common pain reliever could cause medical complications in some people over 65, study suggests


New research has revealed that a common medication might not be safe for everyone.

Acetaminophen, brand name Tylenol, is a pain reliever and fever reducer that’s often included in other drugs, such as cold and flu medicines.

The U.K.-based study — published in Arthritis Care & Research, an official journal of the American College of Rheumatology — analyzed the safety of the drug in older individuals.

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The researchers looked at data for more than 180,000 acetaminophen users compared to 400,000 non-users from 1998 to 2018.

The findings revealed that the use of acetaminophen – sometimes also called paracetamol – was associated with an increased risk of serious medical complications.

Acetaminophen may be found in cough, cold and flu medications, as well as in creams, gels, salves and even suppositories, one gerontologist noted. (iStock)

This includes peptic ulcer bleeding, uncomplicated peptic-ulcers, lower gastrointestinal bleeding, heart failure, hypertension and chronic kidney disease.

In a University of Nottingham press release sent to Fox News Digital, lead study author Professor Weiya Zhang, PhD, clarified that long-term use of the drug should be “carefully considered.”

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“Due to its perceived safety, paracetamol has long been recommended as the first-line drug treatment for osteoarthritis by many treatment guidelines, especially in older people who are at higher risk of drug-related complications,” he wrote.

“While further research is now needed to confirm our findings, given its minimal pain-relief effect, the use of paracetamol as a first-line painkiller for long-term conditions such as osteoarthritis in older people needs to be carefully considered.”

acetaminophen pill box

“This is a good reminder that all medicines used chronically have side effects,” said one physician.  (iStock)

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and senior medical analyst at Fox News, shared his reaction with Fox News Digital.

“It is generally accepted doctrine that acetaminophen is not associated with GI bleeding or advancing kidney disease, but the thinking is starting to change on this front,” said the doctor, who was not involved in the study.

“Yes, over-the-counter medications are still medications.”

There is evidence suggesting that acetaminophen “modulates the same cyclooxygenase-related pathways” as anti-inflammatory drugs like ibuprofen, which can “increase adverse GI side effects,” according to Siegel.

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The large U.K. study, the doctor commented, is limited by “being observational,” as well as by an “inability to track over-the-counter as opposed to prescriptions, which were tracked.”

Another potential limitation was that some users had other contributing factors and behaviors, such as smoking and obesity.

Close-up of woman taking medicine at home.

“By inhibiting prostacyclin, it can increase the risk of bleeding,” a doctor warned about the drug. (iStock)

“Still, this is a good reminder that all medicines used chronically have side effects, and we are not always sure what they are,” he said. “This is why we continue to do post-market analysis and to re-evaluate medicines.”

He continued, “And yes, over-the-counter medications are still medications. Acetaminophen is well-known for its liver toxicity, but there are other side effects as well, as this study suggests.”

Fox News Digital reached out to Kenvue, Inc., maker of Tylenol, requesting comment on the study. 

Risks for older adults

Gerontologist Dr. Macie P. Smith in South Carolina, who was not involved in the study, also reacted to the findings.

“I am happy someone is talking about the side effects of certain medications and how they disproportionately impact … those over [age] 65,” she told Fox News Digital.

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Several medications are not recommended for the older adult population, Smith said.

“Simply because they could tolerate the medications at a younger age does not mean their body can tolerate the same medications at an older age, since their body and brain will change as they age,” she noted.

Man taking medicine

People over age 65 should consult with their doctor before taking medications, experts advise. (iStock)

Some of the complications mentioned in the study, such as GI bleeding, hypertension and kidney disease, can increase the risk of stroke, Alzheimer’s disease, dementia, even premature death, according to Smith.

“I would recommend that older adults consult with their primary care doctor before taking any over-the-counter medications, since acetaminophen can be found in cold and flu medications and in creams and [ointments],” she advised.

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“Anything that is identified as a medication or drug should be discussed with the doctor, as geriatrics is a specialized practice and those who fall under this category should receive specialized care.”

Smith also recommended that older adults use only one pharmacy, so the pharmacist can consult the patient’s “running ledger” of prescription medications.

“I would recommend that older adults consult with their primary care doctor before taking any over-the-counter medications.”

“If someone over the age of 65 comes in for over-the-counter medications, the pharmacist can easily and quickly check for medication side effects and possible interactions between their prescription and OTC medications,” she said.

Acetaminophen in particular should be “taken with caution” and under the direction of a doctor for those 65 and older, she cautioned.

woman's hand ready to take medicine with a glass of water

Older brains and bodies might not be able to handle the types of medication they could at a younger age, experts say. (iStock)

Smith urged older individuals and their caretakers to “read the important information that comes with any and all medications.”

She added, “Don’t hesitate to speak to the pharmacist and/or your doctor about the risks and the benefits, then make an informed decision and choose well.”

For more Health articles, visit foxnews.com/health

In a statement sent to Fox News Digital, Tylenol, owned by Kenvue, Inc., voiced its support for “scientific discovery and exploration through research” as a “company firmly rooted in science.”

Tylenol

Tylenol, owned by Kenvue, Inc., voiced its support for “scientific discovery and exploration through research” as a “company firmly rooted in science.” (iStock)

“TYLENOL, in which acetaminophen is the active ingredient, is indicated to temporarily relieve minor aches and pains and reduce fever. TYLENOL has more than 60 years of clinical use to support its safety and efficacy. When taken as directed, TYLENOL has one of the most favorable safety profiles among pain relievers.”

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The company added, “We stand behind the safety of our acetaminophen products and continue to believe TYLENOL is an appropriate pain relief option for people over age 65.”

Fox News Digital reached out to a number of additional drug manufacturers for comment.



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